| Date | Location | Result | |
| Oct 16, 2021 | Grambling, La. | Grambling State 34, Texas Southern 20 | Box score |
| Oct 09, 2021 | Arlington, Texas | Texas Southern 35, Southern U. 31 | Box score |
| Sep 25, 2021 | Houston, Texas | Rice 48, Texas Southern 34 | Box score |
| Sep 11, 2021 | Waco, Texas | Baylor 66, Texas Southern 7 | Box score |
| Sep 04, 2021 | Houston, Texas | Prairie View A&M 40, Texas Southern 17 | Box score |